Bioproccess

Elcam Medical, a global leader in medical device manufacturing brings decades of OEM expertise to the bioprocessing suite.
Our integrated suite of components ensures integrity, safety, and precision throughout the fluid path.

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Boiproccess-Family
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Bio-Flow-Valve-Stopcock

Bio-Flow Valve Stopcock

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Bio-NIP®-NeedleFree-Connector

Bio-NIP® NeedleFree Connector

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Bio-P-Sensor™

Bio-P-Sensor™

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Bio-Manifold-2

Bio-Manifold

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Bio-Safe2™-Rotator-S2R

Bio-Safe2™ Rotator (S2R)

Precision & reliability at Every Point

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Bio-P-Sensor™

Real-Time Accuracy

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Bio-Manifolds

Customizable Flow Solutions

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Bio-NIP® NeedleFree Connector

Closed, Safe Access

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Bio-Safe2 Rotator™

Connections You Can Trust

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Bio-Flow Valve World-Class Stopcocks

Precision Flow Control

Applications

Technical

Advantages

Configurations

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Single-use pressure sensors

measure the pressure of gases and liquids in bioprocesses.

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Delivering accurate, reliable and cost-effective monitoring across a wide range of bioprocess applications.

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Engineered for Bioprocess needs
• Bioprocessing
• Bioreactor Monitoring
• Filtration
• Purification

Positive Range

0 to 6 psi

6 to 30 psi

30 to 50 psi

50 to 60 psi

Accuracy

±2% of reading

±3% of reading

±5% of reading

±10% of reading

Vacuum Range

0 to -7 psi

-7 to -10 psi

±3% of reading

±5% of reading

Regulatory & Bio Compatibility

• USP Class VI

• USP 665/ BPOG

• ISO 10993-5

• USP788

• REACH

• RoHS

• Extractables & Leachables

• Cytotoxicity

• ADCF

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Ease of use

Full visibility of the flow path

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Reliability & Safety

  • 100% leak testing in -production
  • 100% Pre calibration
  • State of the art molding and assembly processes
  • Highly automated production line, fully controlled by on-line testing
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Customization

  • Flow Connections options – Female to male, 1/8” Barb, 3/16” Barb
  • Different Connectors
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Female to male Luers (ISO 80369-7 standard compliant) 650143

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1/8” Barb, 650145

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3/16” Barb 650144

Applications

Technical

Advantages

Configurations

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Multiple configurations designed to streamline single-use bioprocess assemblies.

Fluid flow control specifications

Pressure Resistance

Sterilization durability

Chemical Compatibility

Parameters

Up to 29 psi (2 bars)

Suitable for ETO and Gamma irradiation

Materials compatible with lipids and agressive drugs

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Integrated design – saving the need for additional Luer to Barb adaptors

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Customizable

2-5 ports,
Luer & barb connection types,
variety of handle types & colors,
raw materials Polysulfone and Polycarbonate

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Elcam’s 2-5 ports with luer connection

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5 gang Manifold with 1/8” barbs

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5 gang Manifold with 3/16” barbs

Applications

Technical

Advantages

Configurations

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Closed-system design for protecting bioprocess applications from contamination

Specifications

Maximum use duration

Residual volume at the valve port

Minimum flow rate

ISO Compliance

Biocompatiblity

Sterilization durability

Material Safety

Parameters

Up to 11 days

0.14mL

150 ml/min under 1 meter water column height

Compliant with ISO 80369-7:2016

Biocompatible according to ISO 10993-1

Compatible with EtO and Gamma Sterilization (up to 25 kGy)

Not made with latex or DEHP

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Normally closed Luer activated valve for contamination protection

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Swabbable valve – enables effective disinfection of valve surface

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Transparent fluid path for better visibility

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Dedicated non-membrane activating cover cap for further assurance against air or microorganisms’ ingress

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Elcam’s off-the-shelf NIP® connectors

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NIP® connector with 1/8” barb for bioprocess applications

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NIP® connector with 3/16” barb for bioprocess applications

Applications

Technical

Advantages

Configurations

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For minimizing leakages, tube tangels, kinks and accidental disconnections in Bioprocess applications

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Ideal for cases where stable luer connection has to be made with barbed connection.

Specifications

Material

Special features

Parameters

Unique flexible material (polyethylene)

360° Spinning lock feature

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Mechanical advantages

  • Reduces mechanical stresses induced during prolonged connection and minimizes crack formation and consequent leakages
  • Prevents leakages due to over-tightening
  • Prevents accidental disconnections
  • Prevents “stuck” luer locks due to adhesion and facilitates easy disconnection
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Safety advantages

Minimizes drug leakages and related adverse events:

Hazardous drug exposure, Air embolism, Microbial ingress

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Workflow advantages

  • Reduces tube kinks and twists in the tubing set
  • Enables rotation of coupled luer lock connections and stopcocks
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Elcam’s  of-the-shelf S2R™ connectors,  Tube OD 4.1, 6.8 mm

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Bio-S2R™ with 1/8” barb

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Bio-S2R™ with 3/16” barb

Applications

Technical

Advantages

Configurations

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Flow control in bioprocess applications

Fluid flow control specifications

Pressure resistance Standard bore stopcocks

Pressure resistance Large bore stopcocks

Sterlization durability

Chemical compatibility

Parameters

Up to 45 psi (3 bars)

Up to 29 psi (2 bars)

Suitable for ETO and Gamma irradiation

Materials compatible with lipids and agressive drugs

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Efficiency

Eliminating the need for additional Luer to Barb adaptors.

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Customization – widest variety

Standard bore, Large bore for High flow applications
Raw materials – Polycarbonate, Polysulfone, Copolyester (Tritan)
Handle types and colors according to request

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Elcam’s off-the-shelf standard Luer stopcocks variety

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Stopcocks with 1/8” barbs for bioprocess applications

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Stopcocks with /16” barbs for bioprocess applications

Samples available. Soon to be commercially available

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FAQ's

Everything you need to know about our products.

What is the Elcam Bioprocess Family ?

The Elcam Bioprocess Family is a portfolio of single-use components designed to support fluid handling, flow control, closed access, secure connections, and pressure monitoring in bioprocess applications. The family includes Bio-Manifolds, Bio-Flow Valves, Bio-NIP® NeedleFree Connectors, Bio-Safe2™ Rotators, and Bio-P-Sensor™ single-use pressure sensors.

 

What applications are Elcam Bioprocess products designed for ?

Elcam Bioprocess products are designed for a range of bioprocess applications, including bioreactor monitoring, filtration, purification. They are designed for flow control, contamination protection, and single-use assembly integration.

What are Bio-Manifolds used for ?

Bio-Manifolds are customizable flow solutions designed to streamline single-use bioprocess assemblies. They support fluid flow control and are available in multiple configurations, including 2–5 ports, Luer connections, and 1/8” or 3/16” barb options.

What are the main advantages of Bio-Manifolds ?

Bio-Manifolds offer an integrated design that can eliminate the need for additional Luer-to-barb adaptors. They are also customizable with different port numbers, Luer and barb connection types, handle types, colors, and raw materials such as polysulfone and polycarbonate

What are Bio-Flow Valves ?

Bio-Flow Valves are stopcocks designed for precision flow control in bioprocess applications. They are available in standard bore and large bore options, including high-flow configurations for bioprocess needs.

What is the Bio-NIP® NeedleFree Connector ?

Bio-NIP® is a normally closed Luer-activated needlefree connector designed to help protect bioprocess applications from contamination. It provides closed, safe access and includes a swabbable valve surface for effective disinfection.

How does Bio-NIP® help reduce contamination risk ?

Bio-NIP® helps reduce contamination risk through its normally closed Luer-activated valve, swabbable valve surface, transparent fluid path, and dedicated non-membrane activating cover cap, which provides additional assurance against air or microorganism ingress.

What is the Bio-Safe2™ Rotator ?

Bio-Safe2™ Rotator, also refered to as BIO-S2R™, is a rotating connector designed to minimize leakages, tube tangles, kinks, and accidental disconnections in bioprocess applications. It is especially suitable when a stable Luer connection needs to be made with a barbed connection.

What are the key benefits of Bio-Safe2™ Rotator

Bio-Safe2™ offers mechanical, safety, and workflow advantages. Its unique flexible raw material (polyethylene) and 360° spinning lock feature help reduce mechanical stress, prevent over-tightening, minimize crack formation and leakage, prevent accidental disconnections, and reduce tubing kinks and twists.

What is the Bio-P-Sensor™ ?

Bio-P-Sensor™ is a single-use pressure sensor that measures the pressure of gases and liquids in bioprocesses. It delivers accurate, reliable, and cost-effective monitoring for applications such as bioprocessing, bioreactor monitoring, filtration, and purification.

What are the key specifications and benefits of Bio-P-Sensor™ ?

Bio-P-Sensor™ has a full pressure range of -11 to 75 psi and an operating pressure range of -10 to 60 psi. It offers full visibility of the flow path, 100% leak testing in production, 100% pre-calibration, and flow connection options including female-to-male Luers, 1/8” barb, and 3/16” barbs. It is also compatible with Gamma irradiation up to 50 kGy and EtO sterilization.

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